氨噻肟头孢菌素(Cefotaxime,缩写CTX)是新近研制成功的第三代头孢菌素,日本抗生物质基准解说( 1982)和美国FDA出版的CFR(1984)皆已收载为药典品种,分别采用微生物法或羟胺比色法作为效价测定的定量方法。但根据CTX的结构特点,它很容易降解产生脱乙酰CTX和脱乙酰CTX闭环内酯,见图1。Berg等报道在pH5.5时形成脱乙酰CTX的速度比打开 Cefotaxime (abbreviation: CTX) is a recently developed third-generation cephalosporin. Japan’s antibiotic reference (1982) and the CFR (1984) published by the U.S. FDA have been included as pharmacopoeial varieties Microbial method or hydroxylamine colorimetric method for the determination of potency. However, according to the structural features of CTX, it is readily degraded to produce deacetyl CTX and deacetylated CTX CL, see Figure 1. Berg et al. Reported that the rate of deacetylation of CTX formed at pH 5.5 was faster than that of deacetylated CTX