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药物是防治疾病的物质基础,而在临床诊断明确后的用药过程中,也可因用药不当而导致一系列与治疗无关的异常反应,使机体的某些组织或器官受损,诱发出所谓“药源性疾病”。 六十年代初,新的镇静药Thalidomide(反应停)投入市场后,出现了数以万计的“海豹症畸形”胎儿,酿成了本世纪最大的药物灾害。随着新药的迅猛增加,临床用药日趋复杂,药源性疾病实为屡见不鲜。1984年3～8月上海市的16所医院1600余份病史用药调查分析,药源性疾病有46例,约占2.8%。国外文献中已出现了“呋喃(口旦)啶肺”、“非那西汀肾”、“阿斯匹林胃”及“四环素牙”等药源性疾病的病名。为此,加强合理用药,以预防或减少药源性疾病,应引起医药界的高度重视。
Drugs are the material basis for the prevention and treatment of diseases. In the course of medication after the clinical diagnosis is clearly made, a series of abnormal reactions unrelated to treatment may also be caused by improper administration, which may damage certain tissues or organs of the body and induce the so-called “ Drug-induced disease. ” In the early 1960s, tens of thousands of “seal abnormalities” fetuses appeared after the launch of the new sedative Thalidomide (Response Stop), which led to the largest drug disaster in the century. With the rapid increase of new drugs, clinical drug use is becoming more and more complex, drug-induced diseases are uncommon. From March to August 1984, more than 1,600 medical records of 16 hospitals in Shanghai were surveyed. Drug-induced diseases accounted for 2.8% of cases. Foreign literature has appeared in the “furan (oral Dan)”, “phenacetin kidney”, “aspirin stomach” and “tetracycline tooth” and other drug-induced disease disease name. To this end, to strengthen the rational use of drugs to prevent or reduce drug-induced diseases, should draw the medical community’s attention.