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本文检测了14例慢性血吸虫病(下称慢血)和19例晚期血吸虫病(下称晚血)患者外周血单核细胞体外经脂多糖诱生白细胞介1(IL-l)的活性。结果慢血和晚血患者的IL-1水平分别为75.63±13.80U和57.18±14.33U,均显著低于对照组(98.58±22.13U),经消炎痛处理,可提高两组患者的IL-1诱生水平。提示IL-1水平降低可能是慢性血吸虫感染患者细胞免疫功能降低的重要机制之一。
In this study, peripheral blood mononuclear cells (PBMCs) were induced to undergo interleukin-1 (IL-1) induction by lipopolysaccharide in 14 patients with chronic schistosomiasis and 19 with advanced schistosomiasis. Results The levels of IL-1 in patients with chronic and late blood were 75.63 ± 13.80U and 57.18 ± 14.33U, respectively, which were significantly lower than those in control group (98.58 ± 22.13U). After treatment with indomethacin, the levels of IL- 1 induced level. It is suggested that the decrease of IL-1 level may be one of the important mechanisms of the decrease of cellular immune function in patients with chronic schistosomiasis infection.