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人们对于慢性阻塞性肺病(COPD)急性呼吸衰竭(ARF)时化学感受器对于每分通气量(V_E)的重要性已进行了诸多探讨,但仍有许多问题尚不清楚。本文通过对COPD患者ARF时在机械通气的条件下进行有关CO_2对通气作用的研究,目的是进一步探讨化学感受器的重要性。观察组25例COPD患者均来自ICU病房(男16例,平均年龄64±2岁,FEV_1 0.85±0.08L,Vc2.08±0.13L,PaO_2 8.2±0.4kPa,PaCO_2 6.2±0.2kPa),入院后插管并进行机械通气(平均3±0.7天),使动脉血气测定结果接近正常,之后患者脱机采用重复呼吸法观察6～8分钟。以26例正常人(男19例,平均年龄35±3岁)做对照,以便使两组受检者在相似的PaCO_2和酸碱基础条件下进行比较。其间P_ECO_2上升的速度COPD患者和对照组分别为0.36±0.13kPa·min~(-1),0.29±0.08kPa·min,两者无差异。每个受试
Much has been said about the importance of chemosensors for minute ventilation (V_E) in chronic obstructive pulmonary disease (COPD) acute respiratory failure (ARF), but many questions remain unclear. In this paper, COPD patients with ARF under the condition of mechanical ventilation on the CO_2 on the ventilation study, the purpose is to further explore the importance of chemoreceptors. Twenty-five patients with COPD in the observation group were enrolled in the ICU ward (16 males, mean age 64 ± 2 years, FEV_1 0.85 ± 0.08L, Vc 2.08 ± 0.13L, PaO 2 8.2 ± 0.4kPa, PaCO 2 6.2 ± 0.2kPa) Intubation and mechanical ventilation (an average of 3 ± 0.7 days), so that the results of arterial blood gas test close to normal, then the patient off-line repeated breathing observation of 6 to 8 minutes. Controls were performed on 26 normal subjects (19 males, mean age 35 ± 3 years) to compare two groups of subjects under similar PaCO 2 and acid-base conditions. In the meantime, the rate of P_ECO_2 rise was 0.36 ± 0.13 kPa · min -1 and 0.29 ± 0.08 kPa · min in COPD patients and controls, respectively. There was no difference between them. Each test