论文部分内容阅读
肿瘤通常会引起疼痛,而目前的常规药物止痛常不能满意地缓解肿瘤患者的疼痛症状,并且或多或少存在一些不良反应。近年来,随着肿瘤疼痛动物模型的不断建立,研究方法的不断改进,肿瘤痛机制的深入研究,在上调抗痛基因表达与下调疼痛基因表达的基本策略的基础上,肿瘤疼痛基因治疗也获得很大的进展。这给临床治疗肿瘤疼痛带来新的希望。现就肿瘤疼痛的基因治疗进行综述。
Tumors usually cause pain, and the current conventional painkillers often can not satisfactorily relieve the pain symptoms of cancer patients, and there are more or less adverse reactions. In recent years, along with the continuous establishment of animal models of tumor pain, continuous improvement of research methods and further study on the mechanism of tumor pain, on the basis of the basic strategy of up-regulating anti-pain gene expression and down-regulating pain gene expression, tumor pain gene therapy is also obtained Great progress. This brings new hope to clinical treatment of tumor pain. A review of gene therapy for cancer pain is now available.