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目的探讨DNA修复基因聚腺苷二磷酸核糖聚合酶-1(PARP-1)单核苷酸多态性位点Val762Ala基因多态性与中国人群乳腺癌易感性的关系。方法采用Sequenom MassARRAY单核苷酸多态性(SNP)基因型分析技术对经病理确诊的原发性乳腺癌女性患者837例(病例组)和健康对照组865例进行PARP-1基因单核苷酸位点Val762Ala基因分型。以非条件logistic回归计算优势比(odds ratio,OR)及其95%可信区间(CI)评价各基因型与乳腺癌发病风险的关系。数据均由SPSS13.0统计软件分析。结果病例组和对照组中TT、TC、CC和TC+CC 4种基因型的分布分别差异无统计学意义,OR[95%CI]值分别为1、1.07(0.83～1.39)、1.03(0.70～1.36)、1.08(0.82～1.33)。结论 Val762Ala基因型与乳腺癌易感性无显著相关性。PARP-1基因Val762Ala多态性在乳腺癌发病过程中无作用。
Objective To investigate the relationship between polymorphism of DNA repair gene ValpA2 (PARP-1) Val762Ala polymorphism and susceptibility to breast cancer in Chinese population. Methods A total of 837 women with primary breast cancer diagnosed by pathology and 865 healthy controls were enrolled in the study. Sequenom MassARRAY single nucleotide polymorphism (SNP) Acid site Val762Ala genotyping. Non-conditional logistic regression was used to calculate the odds ratio (OR) and its 95% confidence interval (CI) to evaluate the relationship between genotypes and the risk of breast cancer. Data were analyzed by SPSS 13.0 statistical software. Results There was no significant difference in the distribution of TT, TC, CC and TC + CC genotypes between case group and control group. The OR [95% CI] values were 1,1.07 (0.83-1.39), 1.03 (0.70 ~ 1.36), 1.08 (0.82 ~ 1.33). Conclusion There is no significant correlation between Val762Ala genotype and susceptibility to breast cancer. PARP-1 gene Val762Ala polymorphism in the pathogenesis of breast cancer no effect.