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目的探讨允许性高碳酸血症进行观察的肺保护性通气策略应用价值,观察其对患儿外周血中炎症介质的影响。方法将60例新生儿呼吸窘迫综合征需应用呼吸机支持治疗的患儿随机分为两组:试验组行肺保护性通气策略共30例,对照组应用传统通气策略(大潮气量通气)共30例。动态观察两组患儿外周血中炎症介质在治疗前后的变化。结果应用两种策略治疗后,两组炎症介质水平均有不同程度的降低的肺保护性通气策略(P均<0.05);但应用传统通气策略治疗的效果不如应用允许性高碳酸血症的肺保护性通气策略(P<0.05)。结论应用两种策略治疗新生儿呼吸窘迫综合征对减少炎症介质的释放均有不同程度的作用;而应用允许性高碳酸血症的肺保护性通气策略具有更好的效果。
Objective To investigate the value of lung protective ventilation strategy for permissive hypercapnia and to observe its effect on inflammatory mediators in children with peripheral blood. Methods Sixty neonates with respiratory distress syndrome were divided into two groups at random: ventilatory supportive therapy was used in the study group. A total of 30 lung protective ventilation strategies were given in the experimental group. The control group was given 30 ventilation strategies (large tidal volume ventilation) example. The changes of inflammatory mediators in peripheral blood of two groups were observed before and after treatment. Results After the two strategies were applied, the levels of inflammatory mediators in the two groups decreased with different degrees of protective ventilation (P <0.05). However, the effect of traditional ventilation was not as good as that of the patients with permissive hypercapnia Protective ventilation strategy (P <0.05). Conclusions The application of two strategies in neonatal respiratory distress syndrome may reduce the release of inflammatory mediators to varying degrees. However, the protective pulmonary ventilation strategy with permissive hypercapnia has a better effect.