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用克山病病区粮组成偏食低钙基础饲料及在饲料中补一定剂量钙、硒与维生素Ｅ（ＶＥ），观察其对大鼠心肌细胞抗氧化酶系活性及在一过性缺氧条件下心肌酶活性的影响。结果表明病区粮组成的偏食低钙饲料引起大鼠心肌组织ＧＳＨ－Ｐｘ、ＳＯＤ及Ｃａｔ活性明显降低．ＬＰＯ含量升高。在ＮａＮＯ２引起的缺氧条件下，心肌多种酶活性下降，而血清酶活性升高．联合补充钙、硒与ＶＥ可显著提高心肌细胞抗氧化酶系活性及增强心肌细胞抵抗缺氧性损害的能力，提示偏食低钙可加重硒和ＶＥ缺乏条件下心肌细胞总抗氧化能力的减退，对缺血缺氧性因素的敏感性增加。
Keshan disease with the composition of food grains of partial eclipse low calcium basic diet and feed to make up a dose of calcium, selenium and vitamin E (VE), observed on myocardial cell antioxidant enzyme activity and in a transient anaerobic conditions Under the influence of myocardial enzyme activity. The results showed that the ward composed of partial eclipse low calcium diet induced myocardial GSH-Px, SOD and Cat activity was significantly lower. LPO content increased. Under the condition of hypoxia induced by NaNO2, the activity of many enzymes in myocardium decreased and the activity of serum enzymes increased. Combination of calcium, selenium and VE can significantly increase the anti-oxidative enzyme activity of cardiomyocytes and cardiomyocytes against hypoxia damage ability, suggesting that partial eclipse low calcium can aggravate selenium and VE deficiencies under the conditions of total myocardial cell antioxidant capacity decreased, Sensitivity to hypoxia and hypoxia increased.