２－甲基四氢呋喃的选择性开环ＭｉｍｅｒｏＰ等［ＴｅｔｒａｈｅｄｒｏｎＬｅｔｔ，１９９４；３５：１５５３］２－甲基四氢呋喃与酰卤ＲＣＯＸ（Ｘ＝Ｃｌ，Ｉ）反应时可在不同位置开环。当Ｘ＝Ｉ，且Ｒ大时主要得到伯碘代酯［ＩＣＨ２ＣＨ２ＣＨ２ＣＨ（ＯＣＯＲ）ＣＨ... Selective ring opening of 2-methyltetrahydrofuran MimeroP et al [Tetrahedron Lett, 1994; 35: 1553] 2-methyltetrahydrofuran can be opened at different positions by reaction with an acid halide RCOX (X = Cl, I). When X = I and R is large, primary iodoester [ICH2CH2CH2CH (OCOR) CH