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目的:研究固本汤联合孟鲁司特治疗成人哮喘的疗效及对炎症因子和机体免疫功能的影响。方法:选取2015年3月~2016年3月在江苏省南通市第一人民医院就诊的120例成人支气管哮喘患者,随机分为对照组和观察组,每组各60例患者,对照组单用孟鲁司特治疗,观察组在对照组的基础上给予固本汤口服,疗程为2周,比较两组患者的临床疗效和主要临床症状,并检测治疗前后两组患者肺功能和炎症因子水平,观察治疗前后机体免疫功能的变化。结果:治疗后观察组总有效率显著高于对照组,主要临床症状(咳嗽、喘息、肺部哮鸣音和湿啰音)及肺功能(FVC、FEV1、PEF)改善显著优于对照组,血清IL-4、IL-6、IL-13、TNF-α及血浆Ig E含量显著低于对照组,血浆Ig A、Ig G显著高于对照组(P<0.01)。结论:固本治疗汤联合孟鲁司特对成人支气管哮喘具有显著的临床疗效,能减轻临床症状,降低气道炎症反应,提高机体免疫功能。
Objective: To study the therapeutic effect of Guben Decoction combined with montelukast on adult asthma and its effect on inflammatory cytokines and immune function. Methods: A total of 120 adult patients with bronchial asthma who were treated in Nantong First People’s Hospital from March 2015 to March 2016 were randomly divided into control group and observation group, with 60 patients in each group. The control group Montelukast treatment, the observation group on the basis of the control group given Guben decoction orally for 2 weeks, the clinical efficacy and the main clinical symptoms were compared between the two groups, and before and after treatment to detect lung function and inflammatory cytokines levels , Observe the changes of immune function before and after treatment. Results: After treatment, the total effective rate in the observation group was significantly higher than that in the control group. The main clinical symptoms (cough, wheezing, lung wheeze and wet rales) and pulmonary function (FVC, FEV1, PEF) Serum levels of IL-4, IL-6, IL-13, TNF-α and plasma Ig E were significantly lower than those of the control group. Plasma Ig A and Ig G levels were significantly higher than those of the control group (P <0.01). Conclusion: Guben Decoction combined with montelukast has significant clinical curative effect on adult bronchial asthma, which can reduce clinical symptoms, reduce airway inflammatory response and improve immune function.