论文部分内容阅读
Stewart于1979年提出降压过度，尤其是舒张压降得过低可能增加心血管疾病并发症风险。此后大量研究逐渐证实了舒张压与心血管疾病之间存在J型曲线关系，并且这种关系同样体现在合并冠心病、糖尿病的高血压患者以及老年高血压患者中。因此，强化降压的理念受到了巨大的冲击，尤其是不同人群中究竟该如何选择降压目标值，再一次成为了临床医生们面临的难题。现在分析归纳一些大型临床试验的结果，对降压过程中低舒张压与心血管疾病的关系做一综述。“,”During the past 3 decades,the J-curve relationship between diastolic blood pressure(DBP)and cardiovascular disease ( CVD) has been a subject of much concern.Numerous studies have provided strong evidence for J-curve relationship between DBP and CVD in the general hypertensive patients,as well as in high-risk populations,including patients with coronary artery disease,diabetes mellitus and the elderly.As a result aggressive blood pressure-lowering has been impacted and physicians are once again stuck for what to choose as a tar-get level.This paper analyzed the result of a few large clinical trials and reviewed the J-curve relationship between DBP and CVD to provide a basis for rational antihypertensive therapy.