核受体成员包括雌激素受体、雄激素受体、视黄酸受体、糖皮质和盐皮质激素受体、甲状腺激素受体、维生素D受体和一些配体尚未确定的“孤儿受体”。核受体为依赖配体的转录因子 ,通过对基因转录的调控影响生长、增殖、分化等细胞生命活动的方方面面。核受体对基因转录的调控是通过对协同调节因子的征集和对染色质的重塑开始的。本文对近年来作者在核受体基因表达调控研究领域的工作进行了总结 ,着重介绍了雌激素受体和雄激素受体在调节基因表达过程中 ,受体与协同调节因子之间、各协同调节因子之间、协同调节因子与基因顺式作用元件之间以及基因各顺式元件 (增强子和启动子 )之间相互作用的方式和机制方面的研究工作 (原文见Cell和MolecularCell)。核受体在不同组织中可以呈现不同的生物活性 ,文章最后总结了作者最近对雌激素受体在乳腺和子宫内膜中所表现的组织特异性的分子机制的探讨工作 (原文见Science) Nuclear receptors include the estrogen receptor, androgen receptor, retinoic acid receptor, glucocorticoid and mineralocorticoid receptor, thyroid hormone receptor, vitamin D receptor and some ligands have not been identified “orphan receptor ”. Nuclear receptors are ligand-dependent transcription factors that affect various aspects of cell life activities, such as growth, proliferation, and differentiation, through the regulation of gene transcription. Nuclear receptors regulate gene transcription through the recruitment of co-regulatory factors and the remodeling of chromatin. This review summarizes recent work done by authors in the field of regulation of nuclear receptor gene expression and emphatically introduces the roles of estrogen receptors and androgen receptors in the regulation of gene expression, (See Cell and Molecular Cell) for the ways and mechanisms involved in the interaction between factors, costimulators, and cis-acting elements of genes and between cis-elements (enhancers and promoters) of genes. Nuclear receptors in different tissues can show different biological activity, the article concludes the author summarizes the recent estrogen receptor in the breast and endometrial tissue expressed in the specificity of molecular mechanisms of work (see text)