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在生物化学教学中,学生常常难以想象和理解酶活性这一重要概念以及温度变动、抑制剂、酶浓度、底物浓度对酶催化反应速度的影响。本文介绍两种帮助学生掌握酶活性概念的比拟教学方法。一、针刺气球比拟法我们不妨让学生想像一个孩子(仿佛一种酶)在一家体育馆内用大头针刺爆气球(相当于底物)的情景。假定气球均位于与孩子齐腰高的位置。如果体育馆内只有一个孩子且每隔十米有一只气球,那么,每秒钟被刺爆的气球数将很少。当增加气球数(球间距离减小)时,孩子在球间移动的距离减小,则刺爆速度将增加。当气球数很多时,孩子尽自己力所能及的速度刺爆气球,但其速度
In biochemistry teaching, students often find it hard to imagine and understand the important concept of enzyme activity as well as the effects of temperature changes, inhibitors, enzyme concentration, and substrate concentration on the rate of enzyme-catalyzed reactions. This article presents two comparative teaching methods to help students grasp the concept of enzyme activity. First, the acupuncture balloon analogy We may wish to allow students to imagine a child (as if an enzyme) in a gym with a pin burst balloon (equivalent to the substrate) scenario. Suppose the balloons are all in the same waist as the child. If there is only one child in the gym and there is a balloon every ten meters, the number of balloons that are stabbed per second will be very small. When the number of balloons is increased (the distance between the balls is reduced), the distance the child moves between the balls is reduced, and the rate of blasting increases. When the number of balloons, the child do their best to blow the balloon, but its speed