白细胞介素8(Interleukin-8,IL-8)是新近发现的一种细胞因子,不仅产生于单核巨噬细胞系统,血管内皮细胞也能分泌IL-8,已知IL-8具有趋化中性粒细胞和T淋巴细胞的活性,参予机体的炎症过程和免疫调节,但其生物学意义目前尚未完全阐明,特别是对心血管系统活动的影响,尚未见报道。本工作观察IL-8对大鼠血压、心率以及对离体大鼠主动脉肌条舒缩活动的影响,探讨其对循环系统的可能调节作用。 Interleukin-8 (IL-8) is a recently discovered cytokine that is not only produced by the monocyte-macrophage system, but also by the secretion of IL-8 by vascular endothelial cells. IL-8 is known to chemotaxis Neutrophil and T lymphocyte activity, participate in the body’s inflammatory process and immune regulation, but its biological significance has not yet been fully elucidated, especially on the cardiovascular system activity, has not been reported. This study was to observe the effect of IL-8 on blood pressure, heart rate and relaxation and contractile activity of aortic strips of isolated rats, and to explore its possible regulation on the circulatory system.