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目前随着激素类避孕药(简称CH)的广泛使用,其对人体的影响特别是对遗传物质的损害作用日益受到重视。有关CH对人体染色体的影响已有报道,但结论时有矛盾。本文旨在进一步明确CH对人体染色体可能的损害作用。作者对44名使用CH和44名从未使用过CH对照妇女的外周血淋巴细胞进行了染色体畸变分析。使用CH的妇女(观察组)和对照组妇女年龄均在16～35岁之间,均无毒物及放射物质接触史。取外周血用含小牛血清的M150培养基培养48小时后,Gimesa染
With the widespread use of hormonal contraceptives (referred to as CH), its impact on the human body, especially the damage to genetic material, has drawn increasing attention. The impact of CH on human chromosomes has been reported, but there are conflicting conclusions. The purpose of this paper is to further clarify the possible damaging effects of CH on human chromosomes. The authors performed a chromosomal aberration analysis of 44 peripheral blood lymphocytes from CH and 44 women who had never used CH. Women in CH group (observation group) and control group were all aged 16-35 years old, with no history of exposure to toxicants or radioactive materials. Peripheral blood was taken for 48 hours after culture in M150 medium containing calf serum, and Gimesa was stained