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促甲状腺素释放因子（TRH）在中枢神经系统（CNS）起着各种重要作用，为一种CNS兴奋药。本文报道了药物的PLGA（dl一乳酸／聚乙二醇）微球在体内、外释放的相互关系及TRH溶液的药动学参数。研究TRH微球是否可提供一种比注射TRH水溶液更方便的治疗脑疾病方法。PLGA微球制备将7gT
Thyrotropin releasing factor (TRH) plays a variety of important roles in the central nervous system (CNS) as a CNS stimulant. In this paper, we report the relationship between drug release of PLGA (dl-lactic acid / polyethylene glycol) microspheres in vitro and in vivo and the pharmacokinetic parameters of TRH solution. To investigate whether TRH microspheres can provide a more convenient method of treating brain diseases than injecting TRH solution. Preparation of PLGA microspheres 7 gT