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目的分析江苏省2008-2014年b型流感嗜血杆菌(Hib)疫苗预防接种不良反应的发生特征,评价Hib疫苗预防接种的安全性。方法通过疑似预防接种异常反应信息管理系统和江苏省预防接种个案信息管理系统,收集江苏省2008-2014年报告的Hib疫苗不良反应个案数据和Hib疫苗接种数据,采用描述流行病学方法对相关指标进行分析。结果 2008-2014年江苏省共报告Hib疫苗不良反应5 352例,平均报告发生率为77.98/10万剂,其中严重异常报告发生率为0.13/10万剂。所有不良反应中,一般反应4 979例,占93.03%;异常反应373例,占6.97%。男、女性别比为1.51∶1,主要集中在≤1岁儿童和首剂接种后。一般反应的主要症状为发热、局部红肿和局部硬结,异常反应的诊断主要为过敏性皮疹。不良反应集中在接种后≤1d。结论 Hib疫苗不良反应以发热、红肿、硬结和过敏性皮疹为主,发生时间主要集中在接种后≤1 d。Hib疫苗具有较好的预防接种安全性,但仍需关注预防接种后急性过敏反应的发生信号。
Objective To analyze the incidence of adverse reactions of vaccination against Hib vaccine (Hib) in Jiangsu Province from 2008 to 2014 and evaluate the safety of vaccination against Hib vaccine. Methods The data of Hib vaccine adverse reactions and Hib vaccination data collected from 2008 to 2014 in Jiangsu Province were collected through the information system of suspected abnormal vaccination response and the information system of vaccination case of Jiangsu Province. The epidemiological method was used to analyze the related indicators Analyze. Results A total of 5 352 Hib vaccine adverse reactions were reported in Jiangsu Province during 2008-2014. The average reported incidence was 77.98 / 100 000, of which the incidence of serious abnormality was 0.13 / 10 000. All adverse reactions, the general reaction of 4 979 cases, accounting for 93.03%; abnormal reaction in 373 cases, accounting for 6.97%. Male and female ratio was 1.51: 1, mainly in ≤ 1 year old children and the first dose after inoculation. The main symptoms of the general response to fever, local redness and local induration, the diagnosis of anorexia mainly allergic rash. Adverse reactions concentrated in the vaccination ≤ 1d. Conclusions Adverse reactions to Hib vaccine are mainly fever, redness, induration and allergic skin rash. The time of occurrence of Hib vaccine mainly concentrates on ≤1 days after inoculation. Hib vaccine has better vaccination safety, but still need to focus on the prevention of acute allergic reaction after vaccination signal.