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[摘要] 目的 探究升阳散火汤治疗复发性口腔溃疡的临床疗效及作用机制。 方法 将2017年10月至2018年12月就诊于牡丹江医学院附属红旗医院耳鼻咽喉科的60例ROU患者随机分成两组，每组各30例，对照组给予常规的复方氯己定含漱液治疗，治疗组给予升阳散火汤治疗，比较两组患者治疗前后临床疗效、血清中炎症因子、氧化应激因子、外周血T淋巴细胞亚群、治疗总有效率及复发率。 结果 两组患者治疗后溃疡个数、溃疡面积、充血面积、中医症候评分较治疗前明显下降（P<0.05），治疗组较对照组下降更为明显（P<0.05）。两组患者治疗后IL-2、SOD、CD3 、CD4 及CD4 /CD8 水平与治疗前相比均升高（P<0.05），且治疗组较对照组升高更加明显（P<0.05），但治疗组治疗后CD8 水平与对照组比较，差异无统计学意义（P>0.05）。疗程期间治疗组的ROU总有效率（96.97%）明显优于对照组（76.67%）（P<0.05），治疗组复发率（10.00%）优于对照组（33.33%）（P<0.05）。 结论 升阳散火汤治疗复发性口腔溃疡疗效肯定。
[关键词] 升阳散火汤;复发性口腔溃疡;中医证候;白介素;超氧化物歧化酶
[Abstract] Objective To explore the clinical efficacy and mechanism of Shengyang Sanhuo Decoction in treating recurrent oral ulcers. Methods A total of 60 patients with ROU in the Department of Otorhinolaryngology in the Hongqi Hospital Affiliated to Mudanjiang Medical College from October 2017 to December 2018 were randomly divided into two groups， with 30 cases in each group. The control group was given conventional compound chlorhexidine gargle treatment： The treatment group was treated with Shengyang Sanhuo Decoction. The clinical efficacy， serum inflammatory factors， oxidative stress factors， peripheral blood T lymphocyte subsets， total effective rate of treatment and recurrence rate were compared between the two groups before and after treatment. Results The clinical efficacy indicators of the two groups including the number of ulcers， ulcer area， hyperemia area， TCM syndrome score after treatment were significantly lower than those before treatment（P
[关键词] 升阳散火汤;复发性口腔溃疡;中医证候;白介素;超氧化物歧化酶
[Abstract] Objective To explore the clinical efficacy and mechanism of Shengyang Sanhuo Decoction in treating recurrent oral ulcers. Methods A total of 60 patients with ROU in the Department of Otorhinolaryngology in the Hongqi Hospital Affiliated to Mudanjiang Medical College from October 2017 to December 2018 were randomly divided into two groups， with 30 cases in each group. The control group was given conventional compound chlorhexidine gargle treatment： The treatment group was treated with Shengyang Sanhuo Decoction. The clinical efficacy， serum inflammatory factors， oxidative stress factors， peripheral blood T lymphocyte subsets， total effective rate of treatment and recurrence rate were compared between the two groups before and after treatment. Results The clinical efficacy indicators of the two groups including the number of ulcers， ulcer area， hyperemia area， TCM syndrome score after treatment were significantly lower than those before treatment（P