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胰腺癌是预后极差的肿瘤,当前各种治疗手段效果均不佳。冷冻在各种实体瘤的治疗中已取得较好效果,但在胰腺癌治疗中的作用报道甚少。体内外实验表明冷冻可毁损肿瘤细胞,安全性好。临床研究显示:冷冻为主综合治疗中晚期胰腺癌,中位生存期达13.4～16个月,1年生存率57.5%～63.6%;安全性好,主要并发症为:胃排空障碍的发生率为0～40.9%;胰漏发生率为0～6.8%;胆漏的发生率为0～6.8%。更为重要的是,肿瘤冷冻消融后,以坏死肿瘤细胞和细胞碎片的形式,释放大量肿瘤抗原,诱导冷冻后免疫,可抑制肿瘤的生长和转移。将局部冷冻消融治疗与全身免疫治疗相结合,可为中晚期肿瘤综合治疗提供新的治疗技术与方法
Pancreatic cancer is a poor prognosis of the tumor, the current treatment of various means are not good. Cryotherapy has achieved good results in the treatment of various solid tumors, but little is known about its role in the treatment of pancreatic cancer. In vitro and in vivo experiments show that freezing can destroy tumor cells and is safe. Clinical studies have shown that: frozen-based comprehensive treatment of advanced pancreatic cancer, the median survival of 13.4 to 16 months, 1-year survival rate of 57.5% to 63.6%; safety is good, the main complications are: the occurrence of gastric emptying disorders The rate was 0 to 40.9%. The incidence of pancreatic leakage was 0 to 6.8%. The incidence of bile leakage was 0 to 6.8%. More importantly, after tumor cryoablation, a large number of tumor antigens are released in the form of necrotic tumor cells and cell debris to induce post-freezing immunization, which can inhibit tumor growth and metastasis. The combination of local cryoablation and systemic immunotherapy can provide new treatment techniques and methods for the comprehensive treatment of advanced cancer