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防老剂4010,促进剂PX在橡胶制品中应用比较广泛,有关资料介绍及我所对这两种材料所做的急性毒性试验结果均属低毒类。为进一步了解其远期作用,我们与中山医学院协作,采用Ames提出的用微生物诱变试验方法,对4010及PX的致突变性进行鉴定,为选用防老剂4010、促进剂PX提供科学依据。材料及方法一、代谢活化系统制备:选用150～200克的雄性大鼠,在取肝前5天,用玉米油配制的聚氯联苯溶液(200毫克/毫升),按每公斤体重500毫克作腹腔内注射进行酶诱导,5天后
Antioxidant 4010, accelerator PX is widely used in rubber products, the information on the introduction and I have done on these two materials acute toxicity test results are low toxicity. To further understand its long-term role, we collaborated with Sun Yat-sen Medical College to identify the 4010 and PX mutagenicity using the microbial mutagenesis test method proposed by Ames, which provided a scientific basis for selecting antioxidant 4010 and promoting agent PX. MATERIALS AND METHODS A. Preparation of metabolic activation system: 150-200 g male rats were selected. Five days before the liver was taken, a polychlorobiphenyl solution (200 mg / ml) made of corn oil was added to 500 mg For intraperitoneal injection for enzyme induction, 5 days later