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由药物副作用及不良反应引起的药源性疾病中以消化道损害尤为多见.本文分析49例药源性消化道病变的病因,以唤起临床注意. 临床资料 49例男30例,女19例,年龄17～75岁,平均54岁,其中≥60岁19例(38.6%).以药物副反应入院者18例(36.7%),住院过程中使用药物致消化道病变者31例(63.13%).从服药到消化道病变发生的时间为1天～3个月。诊断符合国内标准.49例中无一例因药源性消化道病变致死. 药源性消化道病变分析一、上消化道出血23例:基础病变有痛风、肩周炎、粟粒性结核、肠蛔虫症、高血压病、SLE、多发性硬化、感冒等.使用药物为炎痛喜康4例、布洛芬3例、P AS 1例、去痛片3例、左旋咪唑3例、肠溶阿斯匹林2例、强的松2例,氢化考的松1例、地塞米松2例、复方降压片2例.临床表现为黑便和(或)呕血.所致病变为胃溃疡3例、出血性胃炎11例、慢性浅表性胃炎9例.全部病例均
Drug side effects and adverse reactions caused by drug-induced gastrointestinal diseases are particularly prevalent.In this paper, 49 cases of drug-induced gastrointestinal lesions of the etiology to arouse clinical attention.Clinical data 49 cases of 30 males and 19 females , Aged from 17 to 75 years (average 54 years), of which 19 (38.6%) were ≥60 years old.Among 18 cases (36.7%) hospitalized with drug side effects, 31 cases (63.13% ) From taking medicine to gastrointestinal lesions occurred in 1 day to 3 months. Diagnosis in line with national standards.Among 49 cases, none of them died of drug-induced gastrointestinal lesions.Analysis of drug-induced gastrointestinal lesions, a case of upper gastrointestinal bleeding in 23 cases: the basic lesion with gout, frozen shoulder, miliary tuberculosis, intestinal roundworm Symptoms, Hypertension, SLE, multiple sclerosis, cold, etc. Drugs used for inflammatory pain were 4 cases, ibuprofen 3 cases, P AS 1 case, painkiller tablets 3 cases, levamisole 3 cases, enteric-coated 2 cases of aspirin, prednisone in 2 cases, hydrocortisone in 1 case, dexamethasone in 2 cases, compound antihypertensive tablets in 2 cases.Megan clinical manifestations of melena and / or hematemesis.The resulting lesions were gastric ulcer 3 Cases, 11 cases of hemorrhagic gastritis, chronic superficial gastritis in 9. All cases were