大量证据表明血小板激活与肺炎症加重及支气管痉挛相关。卵白蛋白过敏的小鼠经卵白蛋白激发后,监测肺内血小板聚集状况。经变应原激发后,野生型小鼠的血小板从血中迁移到肺内,而有IgE受体缺陷的小鼠(即Fc(?)RIy缺乏的小鼠)无此现象。从变态反应性患者及从野生型小鼠分离到的血小板在体外也向 There is ample evidence that platelet activation is associated with increased lung inflammation and bronchospasm. Ovalbumin-challenged mice were challenged with ovalbumin to monitor platelet aggregation in the lung. After the allergen challenge, wild-type mice migrated platelets from the blood into the lungs, whereas mice lacking the IgE receptor (ie Fc (?) RIy-deficient mice) did not. Platelets isolated from allergic patients and from wild-type mice also target in vitro