Correlation of EGFR, CD146, HIF1α in adenoid cystic carcinoma and their association with tumor angio

来源 :11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲 | 被引量 : 0次 | 上传用户:hznmtz
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Objective: Adenoid cystic carcinoma (AdCC) of the head and neck is characterized by indolent while persistent growth, multiple local recurrences and early distant metastasis.EGF receptor (EGFR) is deemed to have pivotal roles in AdCC progression.This study aims to investigate the correlation between angiogenesis and EGFR signaling pathway.Materials and Methods: The expression of CD 146, CD31, HIF1α, an important angiogenesis regulator, and EGFR was evaluated by immunohistochemical staining using tissue microarray (TMA) containing normal salivary gland (NSG),pleomorphic adenoma (PMA) and AdCC tissues.Pearson correlation analysis was conducted to explore the correlation among EGFR, CD146, HIF1α and CD31.For their similarity and intimacy, hierarchical analysis was performed with Cluster 3.0 and visualized using Java TreeView.
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