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AIM Referring to the relation between hypertension and excessive drinking and high fat diet, we established the hypertension model rats by feeding with alcohol and high glucose and fat diet, which is similar to human diseases.METHODS SD rats, half male and half female, were divided into 3 groups according to their weight.The fnrst group were fed with alcohol and standard diet (the alcohol concentration increased from 5% to 22%).The second group received high glucose and high fat diet and water.The third one, used as normal control group, received standard diet and water.The whole experiment lasted 30 weeks.Blood pressure were measured directly by tail arteries in awake rats.Blood were collected to detect the levels of serum ALT, AST, GGT, ALP, TP, ALB, UA, Cr.RFSULTS After drinking for 8 weeks, the blood pressure of SD rats started to rise significantly.After 17 weeks, the SBP was close to 160 mmHg.After 6 weeks, the blood pressure of SD rats which fed with high glucose and high fat diet started to rise significantly and the SBP was close to 160 mmHg after 15 weeks.In the drinking group or high glucose and high fat group, biochemical indexes which reflect liver and kidney functions appeared abnormal after 12 weeks.CONCLUSION The blood pressure of SD rats could increase to some extent by long-term alcohol consumption or high glucose and high fat diet.At the same time, complications, such as liver and kidney injury, were also observed.