【摘 要】
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The cyclotides are a recently discovered family of plant-derived proteins that have applications in drug design and agriculture.They occur in plants from th
【机 构】
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University of Queensland Australia
【出 处】
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2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
The cyclotides are a recently discovered family of plant-derived proteins that have applications in drug design and agriculture.They occur in plants from the Violaceae (violet),Rubiaceae (coffee) and Cucurbitaceae (cucurbit) families and have a diverse range of biological activities,including uterotonic,anti-HIV,antimicrobial,and insecticidal activities,the latter suggesting that their natural function is in plant defence.Individual plants express suites of 10-100 cyclotides at high levels (2g/kg wet plant weight).Cyclotides typically comprise 30 amino acids,contain a head-to-tail cyclised backbone and incorporate three disulfide bonds arranged in a cystine knot topology.
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