Targeted delivery of drugs to diseased tissues in vivo is important in cancer therapy to decrease side-effect resulting from nonspecific drug distribution and to enhance drug delivery efficiency.We have developed a novel self-assembled DNA nananostructure as a multifunctional vehicle for targeted cancer cell imaging and drug delivery.The novel DNA nanorods are constructed from two oligonucleotides with predesigned base-pairing hybridization.Another oligonucleotide has a part of palindrome sequence that ensure that form the nanomaterial.Whats more,we can tune the size of DNA nanorods by controlling the time of ligation and the concentration of nucleic acids.