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Nanoparticles have emerged as one of the most fascinating drug delivery systems for the controlled delivery of antiturnor drugs to improve therapeutic efficacy and reduce systemic toxicity.The design and development of "smart" nanoparticles seek to expand upon the benefits.In this dissertation, amphiphilic modified dextran and its derivatives were synthesized successfully.Based on these polymers, a smart responsive polymeric lipid vesicle (PLV) system was successfully fabricated.It can be used as a multi-functional platform for tumor diagnosis and therapy.