Metabolite-dependent deneddylation of Cullin Ring E3 Ligases by CSN controls insulin secretion and o

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：howard2000_0

【摘要】

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【作者】

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Feng Rao Tao Wang Hong Lin Yuan Yan Xiaozhe Zhang Li Liu

【机构】

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Department of Biology,South University of Science and Technology(SUSTech),Shenzhen,China

【出处】

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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

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2018年10期

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　　Cullin Ring E3 ligases(CRLs)are a large family of ubiquitin ligases mediating the degradation of~20%of the proteome.CRLs are activated by neddylation and regulated by the deneddylase COP9 Signalosome(CSN).CSN biochemically inhibits but genetically activates CRLs,underscoring the importance of dynamic complex assembly,which remains poorly understood.

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Metabolite-dependent deneddylation of Cullin Ring E3 Ligases by CSN controls insulin secretion and o

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