2. 您的位置
3. 首页
4. 会议论文
5. Epigenetic silencing of Thanatos-associated protein 10 by AML/ETO promotes AML cell proliferation th

Epigenetic silencing of Thanatos-associated protein 10 by AML/ETO promotes AML cell proliferation th

来源 :第四届国际肿瘤表观遗传学大会 | 被引量 : 0次 | 上传用户：lqy760305

【摘 要】

：

t(8;21) is one of the most frequent chromosomal translocations occurring in acute myeloid leukemia (AML) and is considered the leukemia-initiating event.THAP10 with THAP domain structure, and are memb

【作 者】

：

Yonghui Li Mengmeng Jiang Qiaoyang Ning Wenrong Huang Yu Jing Clara Nervi Li Yu 

【机 构】

：

Department of Hematology, Chinese PLA General Hospital, Beijing, 100853, China

【出 处】

：

第四届国际肿瘤表观遗传学大会

【发表日期】

：

2014年8期

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

t(8;21) is one of the most frequent chromosomal translocations occurring in acute myeloid leukemia (AML) and is considered the leukemia-initiating event.THAP10 with THAP domain structure, and are members of the family of newly discovered THAP proteins, its regulatory mechanism is not clear.

其他文献

RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal ca

RASSF10 was frequently found to be methylated in different cancers.To understand the mechanism of RASSF10 in colorectal carcinogenesis, 8 colorectal cancer cell lines, 89 samples of primary colorectal

会议

Epigenetic silencing of DACH1 in triple negative breast cancer contributes to the tumorigenesis

BACKGROUND: Increasing evidence indicates that cell fate determination factor DACH1 functions as a tumor suppressor.Specifically, in estrogen receptor positive (luminal), elevated expression of DACH1

会议

Distinct roles of DNMT1-dependent and-independent methylation patterns in the genome of mouse ES cel

Background: DNA methylation patterns are critical for genome stability and gene transcription, and are initiated by de novo methylases DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomet

会议

DNA methylation patternsgenome stabilitygene transcriptionde novo methyltrans

Aberrant DNA methylation of acute myeloid leukemia cases in a pedigree with MLL3 germline mutations

Unlike genetic aberrations, epigenetic alterations do not modify the DNA coding sequence, and can be reversed pharmacologically.Identifying a particular epigenetic alteration such as abnormal DNA meth

会议

acute myeloid leukemiaDNA methylationhypermethylationhypomethylation

NONCODE and NPInter, two databases providing comprehensive annotations of non-coding RNAs and relate

Non-coding RNAs (ncRNAs) have been implicated in diseases and identified to play important roles in various biological processes.NONCODE (http://www.bioinfo.org/noncode/) is an integrated knowledge da

会议

Decitabine-based therapy in relapsed and refractory patients with advanced solid tumors

Solid tumor patients when progressed into advanced stages have poor prognosis even treated with intensive salvage regimens and are welcome subjects for clinical trial of new agents.Aberrant DNA methyl

会议

Discovery of an Orally Active Subtype-Selective HDAC Inhibitor, Chidamide, as an Epigenetic Modulato

Epigenetic-modulating agents can concurrently target multiple aberrant or compensatory signaling pathways found in cancer cells.However, existing epigenetic-modulating agents in cancer treatment have

会议

Decitabine based cheomotherapy followed by haplotidentical donor lymphocyte infusion for elderly pat

The treatment outcome of elderly patients with acute myeloid leukemia(AML) was unsatisfied generally and novel approaches was necessitated.We conducted a prospective singlearm, multicenter, phase-Ⅱ tr

会议

DecitabineAcute myeloid leukemia (AML)Induction therapyDonor lymphocyte infus

Global Analysis of DNA Methylation Alteration Induced by Jinfukang in Human Lung Cancer Cells

Introduction DNA methylation plays a critical role in the development and progression of various cancers.Lung cancer is one of the leading causes of cancer-related deaths and non-small cell lung carci

会议

DNA methylationMethylCap-seqJinfukangLung cancerTraditional Chinese medicine

Expression and prognostic value of miR-486-5p in patients with gastric adenocarcinoma

Background MicroRNA (miR)-486-5p expression is often reduced in human cancers.However,its expression in gastric carcinoma and its relation to clinicopathological features and prognosis are unclear.

会议