【摘 要】
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Purpose To prospectively investigate age-,gender-and exercise-related changes in the fast-twitch and slow-twitch skeletal muscle(i.e.,tibialis anterior and soleus muscles)of the calves of healthy volu
【出 处】
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中华放射学学术大会2016、中华医学会第23次全国放射学学术大会暨中华医学会第24次全国影像技术学术大会
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Purpose To prospectively investigate age-,gender-and exercise-related changes in the fast-twitch and slow-twitch skeletal muscle(i.e.,tibialis anterior and soleus muscles)of the calves of healthy volunteers with T1ρ MRI.Materials and Methods The study was approved by the institutional review board.A total of 58 healthy volunteers,divided to the groups of young(N=21,12 male,23.5±1.8 years),middle-aged(N=23,13 male,38.0±5.6 years)and elderly(N=26,15 male,55.7±3.8 years)underwent T1ρ MRI scan of their calves.To compare the difference of physical activity,the volunteers after trained by endurance sport(N=9,male,mean age,43.9±3.9 years)and untrained(N=9,male,mean age,44.3±2.9 years)were recruited.Differences in the T1ρ relaxation times were assessed.The correlation coefficients for the association between T1ρ relaxation time and the age or physical activity scores were calculated.Results The average T1ρ relaxation times of the tibial anterior muscle in three groups were significantly lower compared to the soleus muscle(P<0.0001).The higher T1ρ relaxation times of the tibial anterior and soleus muscles in the elderly volunteers(P<0.0001)and in the females(P<0.05)indicated significant age-dependent differences with respect to the type of skeletal muscle and gender.The higher T1ρ relaxation times in the soleus muscle and lower in the tibial anterior muscle after trained by endurance sport(P<0.05)suggested muscle fiber type change after exercise.Conclusion T1ρ relaxation times can be used to differentiate differences in the tibial anterior and soleus muscles as well as age-,gender-and exercise-related changes.T1ρ MRI is a promising and non-invasive tool for evaluating physiological and pathological changes and muscle response to therapeutics.
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