Oxidative stress is involved in a variety of diseases.Prospective studies investigating the relationship between oxidative stress biomarkers and the occurrence and development of colorectal cancer (CRC) are scarce;previous studies failed to establish a relationship between the serum total oxidant/antioxidant status of CRC patients,oxidative stress,and CRC.Therefore,we compared the total serum oxidant/antioxidant levels of CRC patients and healthy subjects,and analyzed their clinical significance in the diagnosis of CRC.