小檗碱衍生物抑制淋巴瘤细胞增殖及刺激免疫应答的作用研究

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:tengjun1008
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Burkitts lymphoma(BL)is a highly aggressive non-Hodgkins lymphoma,with remarkable cell proliferation and metabolism.The oncogene c-Myc highly expresses in BL and plays a key role in facilitating tumor progression and maintaining a malignant phenotype[1].
其他文献
As an endogenous insulinotropic hormone,Glucagon-like peptide-1(GLP-1)has tremendous potential in treating type Ⅱ diabetes.However,it will be rapidly inactivated by dipeptidyl peptidase Ⅳ(DPP-Ⅳ)at the
The RAF/MEK/ERK and PI3K/PDK/AKT are two of the most frequently dysregulated signaling cascades in human NSCLC,which are involved in the regulation of cell growth and survival.Molecular alterations in
Alzheimers disease(AD)is a fatal neurodegenerative disease with the deterioration of cognitive and memory functions.Homologous α7 nicotinic acetylcholine receptors have high calcium permeability,which
Nicotinic acetylcholine receptors(nAChRs)are members of Cys-loop ligand gated ion channels superfamily.The α7 nAChR,a homopentamer composed of five α7 subunits,has been implicated in diseases associat
Combretum caffrum(Combretaceae)是南非combretum属植物,从中分离出来一系列活性组分Combretastatins.其中以Combretastatin A-4(CA-4)的活性最好,其水溶性衍生物CA4P和AVE-8062目前已进入临床Ⅲ期,CA4P的二代衍生物CA1P亦进入了临床Ⅰ期试验阶段.
Tubulin-microtubule system is an important target for the development of anticancer drugs over the past decades because of its crucial involvement in mitosis.[1] In this paper,a series of novel chalco
Currently,there are 366 million people in the world affected diabetes mellitus,and the number may increase to 522 million by 20301a.a-Glucosidase inhibitors can delay the hydrolysis of carbohydrates,t
组蛋白去乙酰化酶抑制剂(Histone deacetylases inhibitors,HDACis)是一类能够诱导细胞凋亡,抑制肿瘤生长的活性分子。目前已有三个HDACis被美国FDA批准用于治疗淋巴癌以及多发性骨髓瘤[1]。
Human APOBEC3G(apolipoprotein B mRNA-editing enzyme,catalytic polypeptide-like 3G,A3G)is a potent restriction factor against human immunodeficiency virus type 1(HIV-1)by inducing hypermutation of G to
Diterpenoids,a largest group of natural products,are the focus of natural drug discovery due to their structural diversity and wide range of biological activities.Recently,as part of our continuing ef