In the modern society, the drinking alcohol related to social health problem is more and more outstanding, in daily anesthesia and surgery may encounter more and more inthe long-term drinking patients.Peoples general point is, the dosage of anesthetic drugs in long-term drinkers is larger than normal people, however, the relevance for alcohol drinking and anesthesia has been controversial[1,2], perhaps this is relevant with the levels and patterns of alcohol consumption for including subjects was different.