Background: Fibroblast growth factor receptor 1 (FGFR1) plays an important role in proliferation of human glioma.In response to receptor activation, several signaling cascades are induced and receptor/ligand complexes subsequently internalized.The endocytosed receptor remains signaling active until being absorbed into multivesicular bodies.This is followed by transfer of the receptor to the lysosome for final degradation.The receptor can escape this fate via recycling back to the cell surface remaining signaling active or re-activatable.