The purpose of this study was to evaluate the influence ofgrayscale liquid crystal displays (LCD) with different resolutions on the interpretation of chest radiographs.This study used 93 DR chest images with 35 proven non-calcified pulmonary nodules and 58 normal ones.Nine radiologists,three high-experienced radiologists, three mid-experienced radiologists and three low-experienced radiologists, took part in the image reading test on three different types of displays, respectively.Those radiologists were asked to rank the image quality of each radiograph according to the visibility of markings midst upper field of right lung by using a three-point rating scale.They were also asked to rank each radiographs regarding the presence of abnormalities by using a five-point rating scale,simultaneously.SPSS 13.0 was used for the data statistical analysis.For the significance of preference for the three types of displays, we used paired t-test; and for the observer performance of nodular detection, the data was analyzed in terms of the receiver operating characteristic (ROC).The results showed that for the preference test, there were no significant difference among most reading modalities, however, on the 5-megapixel display, the difference was significant between low-and high-experienced radiologists and between mid-and high-experienced radiologists; for the test of detection performance of pulmonary nodules, the difference among different reading modalities did not reach the substantial level.In conclusion, the nodule detection performances on the three monochrome LCDs were found to be equivalent; high-experienced radiologists could get more information on 5-megapixel LCD, and mid-and low-experienced radiologists had the same preference for the three types of monochrome LCDs.