The Potential Role of Alu Y in the Development of Resistance to SN38 (Irinotecan) or Oxaliplatin in

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户:stormcn
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background: Irinotecan (SN38) and oxaliplatin-being part of FOLFIRI or XELOX/ FOLFOX treatment protocols, respectively-are commonly used in the treatment of colorectal cancer patients.However, the frequent development of resistance to these drugs represents a considerable challenge in the clinic.
其他文献
Background: This statistical method is proposed to detect genes whose expression in a single or small number of tissues is significantly different than in other tissues.Tissue specific expression gene
Background: With the increasing prevalence of bacteria antibiotic resistance, phage therapy has become a hotspot in biomedical research.As bacterial viruses, bacteriophages widely exist in various nat
Motivation: The high redundancy of and high degree of cross-talk between biological pathways hint that a sub-pathway may respond more effectively or sensitively than the whole pathway.However, few cur
会议
Background: Adverse drug reactions (ADRs) is one of the main causes of new drug discovery failure.Therefore, it is desired to evaluate drug (or candidate) safety in early laboratory stage before they
Background: Cancer is the leading cause of death all over the world.The molecular mechanisms of cancer occurrence, development and metastasis are quite complicated.A lot of studies have been done for
Background: Alzheimers disease (AD) and Parkinsons diseases (PD) are major neurodegenerative diseases.Previous studies have provided insights into the impacts of genetic factors on AD and PD, and some
Background: Finding candidates for cancer-associated genes are of great value for the prevention, diagnosis and treatment of cancer.Besides classic assays of molecular biology high-throughput technolo
Background: Genetic recombination is an important factor to change and shape genome and its relevant phenotypes.Gene transfer or reassortment and recombination in the nature happen quite frequent betw
Background: Against a declining trend of global HIV epidemic, HIV infection among men who have sex with men (MSM) was reported to be continuously increasing.We assess HIV burden representative by meas
Background: DNA methylation is one of the essential epigenetic mechanisms that are closely correlated with the prognosis progression in non-small cell lung cancer (NSCLC).Advances in computational app