Prediction of Renal Disorders Based on Similarity of Molecular Fingerprint

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户:gauxten01
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background: Adverse drug reactions (ADRs) is one of the main causes of new drug discovery failure.Therefore, it is desired to evaluate drug (or candidate) safety in early laboratory stage before they reach further pre-clinical or clinical stages of drug discovery.
其他文献
Background: Transcription factors (TFs) play key roles in gene expression regulation, so do the transcription cofactors and chromatin remodeling factors.Identifying them are primary and crucial steps
Background: The identification and analysis of tissue specificity of genes and gene expressions have a direct and profound impact on further understanding of a wide array of problems of much significa
Background: Identification of differential expressed genes can expose disease disordered pathways.Currently, Most calculated methods only distinguish researches based on different disease types.Howeve
Inferring gene regulatory networks based on gene expression profiles is an import topic in computational systems biology.Though dozens methods has been proposed in the last decade, current algorithms
Background: Population structure (PS), including population stratification and admixture, is a significant confounder in genome-wide association studies (GWAS) as it may produce spurious associations.
Background: Over the last decade, an increasing number of integrative studies on driver genes has been published.Integrative analysis could overcome the limitation of a single data type, and provide a
Background: DNA methylation plays pivotal roles in gene regulation during tumor initiation and progression, and many cancer epigenetic studies have been devoted to identifying differentially methylate
Background: This statistical method is proposed to detect genes whose expression in a single or small number of tissues is significantly different than in other tissues.Tissue specific expression gene
Background: With the increasing prevalence of bacteria antibiotic resistance, phage therapy has become a hotspot in biomedical research.As bacterial viruses, bacteriophages widely exist in various nat
Motivation: The high redundancy of and high degree of cross-talk between biological pathways hint that a sub-pathway may respond more effectively or sensitively than the whole pathway.However, few cur
会议