The growth of nanoparticles embedded in a host matrix can lead to substantial strain.Strain and its spatial distribution have pronounced influences on the properties of nanoparticles.Nanoparticles embedded in amorphous dielectrics matrix were fabricated using pulsed laser deposition method and rapid thermal annealing technique.The influence of strain on the crystal growth and microstructure development of nanoparticles and the correlation of the physical properties of nanoparticles with their microstructure were investigated.It was revealed that the strain can be a major factor restricting the crystallization of nanoparticles, depending on several factors, the most important of which are the size of the nanoparticles and the growth conditions.With the growth of nanoparticles, the nanoparticles experience stronger and net deviatoric strain, which includes uniaxial and shear strain.Strain-induced changes in lattice parameters alter the intrinsic interatomic distances and modify the energy levels of the bonding electrons, thereby significantly changing the physical properties of the nanoparticles.Strain engineering is an effective tool for tailoring the properties of nanoparticles.