【摘 要】
：
DNA-PKcs is an important molecule of non-homologous end joining repair of double strand breaks.Once DNA double strand breaks occurs, DNA-PKcs could be recruited to DNA damaged site within several seco
【机 构】
：
Beijing Institute of Radiation Medicine, Beijing 100850;School of Medicine, Shihezi University,Shihe
论文部分内容阅读
DNA-PKcs is an important molecule of non-homologous end joining repair of double strand breaks.Once DNA double strand breaks occurs, DNA-PKcs could be recruited to DNA damaged site within several seconds.Defect of DNA-PKcs leads to a decreased repair ability of DNA double strand breaks and an increased radiosensitivity.In addition to damaged DNA repair,DNA-PKcs plays important role in regulating mitosis process of irradiated cell and is a key molecule to couple damaged DNA repair and mitosis process.DNA-PKcs participates G2 checkpoint of irradiated cell, regulates mitosis process and maintains centrosome and spindle stability.
其他文献
Many published studies have indicated that the growing application of complementary and alternative medicine, particularly Traditional Chinese Medicine (TCM) use in combination with conventional cance
Epidemiological studies suggest that an increase of diesel exhaust particles (DEP) in ambient air corresponds to an increase in hospital recorded myocardial infarctions and atherosclerosis after expos
皮肤为阻挡环境物质暴露的主要屏障,可以阻挡许多有害的物质.在评估化合物暴露之伤害时,化合物穿皮能力是重要的考虑因素.过去研究一般利用实验方法测量化合物穿皮能力,然而耗时费力,因此若能开发准确的计算方法预测化合物穿皮能力来初步筛选化合物,再利用实验方法确认化学物质穿透皮肤组织的能力,便能加速化合物暴露风险评估过程并减少实验动物使用,同时也能应用于发展穿皮药物.本研究首先从文献中搜集了197个化合物之
Maternal bacterial infections during pregnancy represent a significant risk factor in neuropsychiatric disorders with a presumed neurodevelopmental failure.The down-streaming syndrome, neuroinflammati
能源危机与环境污染问题近年来广受世界各国所重视,无不积极投入研发替代能源以及减少环境污染排放.而麻疯树籽实含油量(39％)较一般籽类作物高,为深具潜力的生质燃料原料来源,与柴油相较起来,麻疯树油动态黏度(4.2mm2/s)、密度(881 kg/cm2)、十六烷值(48.1)及燃料消耗率(231 g/kW-h)较高,热值(39.6 Mj/kg)、制动热效率则较低,其特性的差异也使引擎的性能发生不同的
DEHP, Di-(2-ethylhexyl) phthalate, the most common phthalate plasticizer used in the production ofpolyvinyl chloride (PVC).Several in vivo studies have shown that DEHP absorbed in the body is metaboli
食品安全为全世界的重要议题，食用遭受微生物及加工过程之化学物等污染之食物将会危害人体健康.邻苯二甲酸二(2-乙基己基)酯(diethylhexyl phthalate；DEHP)，常添加于聚氯乙烯产品中以增加材质的延展性，且广泛应用于建材、汽车产品、食品包装、儿童产品与医疗用品等.DEHP因其非以共价键与材料键结，常会因加热或磨损而从塑料产品释放以污染食品及环境.目前人类暴露DEHP多经由饮食途径
Acrylamide (AA) is a widely-used industrial chemical, present in tobacco smoke and high-temperature processed foods, and classified as a probable human carcinogen.Metabolic activation from AA to glyci
DEHP is the most abundant phthalate plasticizer in polyvinyl chloride (PVC) formulations, including vinyl flooring, wall covering, food containers, gloves, and infant toys.It can be leached into a liq
[目的]石墨烯量子点(GQD)是一种小于100nm的新型碳纳米材料,GQD独特的物理/化学性质使其在包括生物/医学在内的多个领域受到广泛关注。但是,关于GQD诱发的生物学反应和其毒理学研究尚刚刚起步,很大程度上限制了GQD在生物医学领域的应用。本工作研究羟基化修饰石墨烯量子点(GQD-OH)的细胞毒作用。