Diesel exhaust particles cause ROS-induced autophagy and apoptosis in endothelial cells

来源 :第八届海峡两岸毒理学研讨会 | 被引量 : 0次 | 上传用户：liying09

【摘要】

：

【作者】

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Jhih-Syuan Wang Chia-Yi Tseng Ming-Wei Chao

【机构】

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Department of Bioscience Technology, Chung Yuan Christian University, Zhongli district, Taoyuan city

【出处】

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第八届海峡两岸毒理学研讨会

【发表日期】

：

2015年5期

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　　Epidemiological studies suggest that an increase of diesel exhaust particles (DEP) in ambient air corresponds to an increase in hospital recorded myocardial infarctions and atherosclerosis after exposure.However, the detail by how DEP cause endothelial cells death remains unclear.To elucidate the mechanism, we used a human umbilical vein endothelial cell (HUVEC) culture model system.Automobile DEP were resuspended then added immediately at 25 and 50 μg/mL medium-diluted DEP solution to the dishes.

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Diesel exhaust particles cause ROS-induced autophagy and apoptosis in endothelial cells

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