【摘 要】
：
Multidrug resistance (MDR) caused by human ABCB1 (P-glycoprotein /MDR1) is one of the major obstacles in chemotherapy.To circumvent MDR, we screened natural com
【机 构】
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Department of Applied Biological Chemistry, College of Bioscience and Biotechnology, Chubu Universit
【出 处】
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2012上海中医药与天然药物国际大会
论文部分内容阅读
Multidrug resistance (MDR) caused by human ABCB1 (P-glycoprotein /MDR1) is one of the major obstacles in chemotherapy.To circumvent MDR, we screened natural compounds using the human T-cell lymphoblast-like cell line CCRF-CEM and its MDR counterpart (CEM/ADR5000 cells).Four guanidine alkaloids from Pterogyne nitens (galegine, pterogynine, pterogynidine, nitensidine A) were found to exert toxicity against CCRF-CEM cells, whereas CEM/ADR5000 cells were resistant to these alkaloids.Cells expressing human ABCB1 also showed resistance against the cytotoxic guanidine alkaloids.These results suggest that the four guanidine alkaloids are substrates for human ABCB1.
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