Copper-Catalyzed Synthesis of Furo[3,2-c]coumarin And Dihydrofuro[3,2-c]coumarin Through Propargylat

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：kittyleung1979

【摘要】

：

　　A novel copper-catalyzed and microwave-promoted propargylation/alkyne oxacyclization/isomerization cascade for the synthesis of furo[3,2-c]coumarin in moder

【作者】

：

Xiao-YanZhang[1]Li-LiHu[2]ZeShen[2]Zhong-ZhuChen[2]Zhi-GangXu[2]Shi-QiangLi[2]Jian-WuXie[3]Hai-LeiCui[2]

【机构】

：

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,Department of Chemistry

【出处】

：

中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

：

2015年期

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　　A novel copper-catalyzed and microwave-promoted propargylation/alkyne oxacyclization/isomerization cascade for the synthesis of furo[3,2-c]coumarin in moderate to good yields(up to 80%yield)using readily available 4-hydroxycoumarins and terminal propargyl acetates as starting material has been developed.By switching the solvent DMSO to DCE,a range of 2-methylene-2,3-dihydrofuro[3,2-c]coumarin could be obtained in acceptable to good yields(up to 85%yield).

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Copper-Catalyzed Synthesis of Furo[3,2-c]coumarin And Dihydrofuro[3,2-c]coumarin Through Propargylat

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