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Purpose: To investigate the function and mechanism of the amoxicillin loaded silk fibroin coating Methods: The prepared coatings were characterized using fluorescence microscopy,scanning electron microscopy,Fourier transform infrared spectroscopy,X-ray diffraction,shear bond strength testing and antibiotic test.Results: The characterization of the obtained coatings indicated that the intermolecular hydrogen bonds formed between the backbone of silk fibroin and amoxicillin molecular.The amoxicillin loaded coating showed remarkable antibacterial activity against gram-positive(Staphylococcus aureus)and gram-negative(Escherichia coli)bacteria.Conclusion: Electrophoretic deposition was an effective and efficient technique to prepare amoxicillin loaded silk fibroin coatings on the titanium surface and that the coatings with antibacterial property were promising candidates for further loading of functional agents.