Sulfation of Melatonin: enzymatic characterization, differences of genders,organs and species, and b

来源 :2015第11届全国药物和化学异物代谢学术会议 | 被引量 : 0次 | 上传用户：laoxuslx

【摘要】

：

　　Exogenous melatonin (Mel) is widely used in clinic for multiple therapeutic purposes.In metabolism pathways of Mel,6-hydroxymelatonin-sulfate (S-O-Mel) and

【作者】

：

XianggeTian[1]XiaokuiHuo[1]BaojianWu[2]XiaoboWang[3]ChaoWang[1]XiaochiMa[1]

【机构】

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College of Pharmacy, Academy of Integrative Medicine, Dalian Medical University, Dalian, 116044, Chi

【出处】

：

2015第11届全国药物和化学异物代谢学术会议

【发表日期】

：

2015年期

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　　Exogenous melatonin (Mel) is widely used in clinic for multiple therapeutic purposes.In metabolism pathways of Mel,6-hydroxymelatonin-sulfate (S-O-Mel) and N-acetylserotonin sulfate (S-NAS) are the most abundant metabolites account for over 90% of total Mel metabolites in humans, indicating that sulfation plays an important role in reflecting the functions and clearance of Mel in vivo.

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Sulfation of Melatonin: enzymatic characterization, differences of genders,organs and species, and b

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