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Is increasingly used Reduces local recurrences Improves survival Allows organ-preservation in small tumors Is a part of the treatment of solid tumors as well as hematological malignanciesIn some cases is associated with increasing of RISCahans definition (1948) is still the standard Prior history of radiation therapy Asymptomatic period of several years The occurrence of a sarcomawithin a previously irradiated field Histological confirmation of sarcmatous nature of the post irradiation lesion