【摘 要】
：
Plant derived triterpenoid saponins are involved in plant defense system by affecting membrane of bacteria.A series of ocotillol-type triterpenoid derivatives were synthesized starting from PPD,one of
【机 构】
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School of pharmacy,Yantai University,Yantai 264005,R.P.China
【出 处】
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全国药物化学学术会议暨第四届中英药物化学学术会议
论文部分内容阅读
Plant derived triterpenoid saponins are involved in plant defense system by affecting membrane of bacteria.A series of ocotillol-type triterpenoid derivatives were synthesized starting from PPD,one of the main components of Panax ginseng and their antibacterial activity against several representative bacteria were evaluated.Compounds 5 and 11 exhibited excellent antibacterial activity with MIC values of 1 ?g/mL against Staphylococcus aureus and 8,4 ?g/mL against Bacillus subtilis,respectively.Furthermore,Compounds 5 and 11 combined with two commercial antibiotics kanamycin(KAN)and chloramphenicol(CHL)showed strong synergistic activity at their sub-MICs against S.aureus USA300 and B.subtilis 168.Moreover,chloramphenicol turned from bacteriostatic to bactericidal agent when combined with 11 against B.subtilis 168.
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