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  5. Preparation of paeonol transdermal delivery systems based on the microemulsion-based gels and the ch

Preparation of paeonol transdermal delivery systems based on the microemulsion-based gels and the ch

来源 :2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：zhufutao2
【摘 要】
：
Objectives:To investigate the pharmacokinetics of paeonol microemulsion,microemulsion-based gels and marketed paeonol ointments by the skin-blood synchronous microdialysis coupled with LC/MS.Methods:T
【作 者】
：
LIU Ji-Yong HAN Ying ZHU Quan-Gang SUN Hua-Jun GAO Shen 
【机 构】
：
Department of pharmacy,Changhai Hospital,the Second Military Medical University,Shanghai 200433
【出 处】
：
2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
【发表日期】
：
2012年10期
【关键词】
：
paeonol microemulsion based gels microdialysis transdermal delivery systems phar 
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　　Objectives:To investigate the pharmacokinetics of paeonol microemulsion,microemulsion-based gels and marketed paeonol ointments by the skin-blood synchronous microdialysis coupled with LC/MS.Methods:The microdialysis systems were established by linear probes and concentric circles probes.In vivo recovery of paeonol in skin is 69.7±4.8% and in blood is 51.6±7.2%.The paeonol microemulsion,microemulsion based gels and marketed paeonol ointments were administrated to rats.PBS (pH7.4) served as perfused solution.
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