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Objective: this study is intended to observe hemostatic effect of spleen-invigorating,qi-replenishing and blood-containing formula on simvastatin-induced zebrafish hemorrhage model compared with that of clearing heat and cooling blood formula.Method: zebrafish from breed A and breed B were treated with 0.5 μ M simvastatin for 24 hours to establish zebrafish hemorrhage model.Under strict blinded experimental conditions,the zebrafish above were then treated with experimental drug of different concentrations within the maximum non-lethal dose.