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胰淀素是2型糖尿病患者胰岛淀粉样沉积的主要成份。胰淀素可诱导胰岛β细胞凋亡,促进2型糖尿病发生发展。肥胖症和早期2型糖尿病患者血浆胰淀素水平升高,其机制尚不清楚。鉴于肥胖症是2型糖尿病的重要危险因子,肥胖症患者血中脂肪酸、炎症因子(TNF-α、IL-6、MCP-1等)显著升高,我们利用小鼠胰岛β细胞株MIN6及原代培养小鼠胰岛研究了脂
Amylin is a major component of amylin deposition in patients with type 2 diabetes. Amylin can induce pancreatic β-cell apoptosis and promote the development of type 2 diabetes. Obesity and early type 2 diabetes, plasma amylin levels, the mechanism is unclear. Since obesity is an important risk factor for type 2 diabetes, the levels of fatty acids and inflammatory cytokines (TNF-α, IL-6 and MCP-1) in obese patients are significantly increased. We used mouse pancreatic β cell line MIN6 and original Fetal lipids were cultured on mouse islets