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目的探讨核辐射损伤犬脑镜下病理改变及磁共振弥散加权成像定量分析的价值。方法选取健康杂种犬25条,使用60Coγ射线一次性照射犬脑右颞部70Gy制作动物模型。分别对照射前和照射后第2、4、8、10、12周犬脑进行MRI T1WI、T2WI和DWI检查,分别测量犬脑脑白质、脑灰质ADC值,并通过光镜和电镜观察其组织学改变。结果犬脑正常白质的ADC值是(71.89±4.97)×10-5mm2/s,灰质是(69.77±4.33)×10-5mm2/s,全脑组织是(70.83±4.74)×10-5mm2/s。核辐射损伤后各测量时间点犬脑组织的ADC值明显下降,与对照组比较P均<0.05,差异有统计学意义。结论核辐射损伤犬脑在解剖影像学尚未出现异常改变之前已存在微观的病理变化;DWI是一种极其敏感的探测水分子弥散能力变化的功能性成像技术,能够先于解剖影像学发现核辐射损伤犬脑的微观病理改变并通过测量辐射损伤组织的ADC值加以定量分析,有重要的临床应用价值。
Objective To investigate the value of quantitative analysis of pathological changes in canine cerebrum under magnetic radiation injury and diffusion weighted imaging in magnetic resonance imaging. Methods Twenty-five healthy mongrel dogs were selected and the animals were treated with 60Co γ-rays to irradiate the canine right temporal gyrus at a dose of 70 Gy. MRI brain DWI, T2WI and DWI were performed on the 2nd, 4th, 8th, 10th and 12th week before and after irradiation respectively. The ADC value of white matter and gray matter of canine brain were measured, and their tissues were observed by light and electron microscope Learning to change. Results The ADC values of normal white matter in canine brain were (71.89 ± 4.97) × 10-5mm2 / s, gray matter (69.77 ± 4.33) × 10-5mm2 / s and total brain tissue (70.83 ± 4.74) × 10-5mm2 / s . The ADC value of canine brain tissue in each time point after the radiation injury was significantly decreased, P <0.05 compared with the control group, the difference was statistically significant. CONCLUSION: There is a micro-pathological change in the canine brain prior to the abnormal changes in anatomical imaging. DWI is an extremely sensitive functional imaging technique for detecting changes in the diffusivity of water molecules. It can detect nuclear radiation prior to anatomical imaging The microscopic pathological changes of canine brain damaged and quantitative analysis by measuring the ADC value of radiation damaged tissue have important clinical value.